On October 24, 2020, the 4th China Psoriasis Congress "Basic Research and Clinical Diagnosis and Treatment of Psoriasis" academic activity continued in Hefei Fengda International Hotel, Anhui.

The first half of the meeting was co-chaired by Professor Zhang Anping from the first Affiliated Hospital of Anhui Medical University and Professor Kang Xiaojing from Xinjiang Uygur Autonomous Region People's Hospital.

Professor Zhang Xibao, director of the Institute of Dermatology, Guangzhou Medical University and head of the Department of Dermatology, first Shared with us the development process of psoriasis treatment, the application and prospect of targeted and precise treatment of skin diseases.

Dr. Guihua Jin, a team of Professor Zhehu Jin from The Affiliated Hospital of Yanbian University, described the mechanism of B cells in the pathogenesis of psoriasis, and discussed the regulation of dihydroartemisinin on psoriasis, bringing a new direction for basic research and clinical diagnosis and treatment of psoriasis.

From the perspective of the relationship between psoriasis and osteoporosis, Professor Zheng Houfeng of Westlake University elaborated on how to use large biobanks to guide clinical research, providing clinicians with new research ideas.

Chen Aijun, a professor from the First Affiliated Hospital of Chongqing Medical University, introduced the progress of clinical treatment of pustular psoriasis in detail, described the difficulties in the treatment of pustular psoriasis from practical examples, and emphasized that biological agents provided new hope for the treatment of pustular psoriasis.

Based on the influence of metabolic syndrome on the pathogenesis and treatment of psoriasis, Professor Wang Rui from Professor Li Chengxin's team in the First Medical Center of PLA General Hospital pointed out that fat reduction and insulin sensitization can improve the resistance of metabolic syndrome to psoriasis, providing a new idea for the treatment of an important comorosis-metabolic syndrome in psoriasis.

Psoriasis is a chronic disease that is refractory and prone to relapse. Drugs and methods for the treatment of psoriasis are increasingly emerging. Professor Kang Xiaojing of Xinjiang Uygur Autonomous Region People's Hospital, combined with the psoriasis guidelines, has brought us a new perspective for the diagnosis and treatment of psoriasis and described in detail the standardized treatment of psoriasis.

The second half of the meeting was presided over by Professor Geng Songmei from the second Affiliated Hospital of Xi 'an Jiaotong University Medical College and Professor Gao Min from the first Affiliated Hospital of Anhui Medical University.

Professor Zhao Yi from Beijing Tsinghua Changgung Hospital introduced to us the individualized exploration of biological therapy for psoriasis, and Shared his experience to us, providing us with a new perspective in the future diagnosis and treatment.

Xi 'an jiaotong university school of medicine, the second affiliated hospital song-mei geng professor introduced the biological agents in children, pregnancy and lactation women, elderly people, chronic infection, perioperative, merging other diseases, such as different psoriasis using expert consensus and matters needing attention in the population, and pointed out that for special psoriasis people use biological agents should evaluate the pros and cons.

Professor Guan Xin from Peking University Third Hospital focused his attention on pustular psoriasis and Shared with the participants the progress and clinical experience of biological agents in the treatment of pustular psoriasis through clinical cases and guidelines.

From a new perspective, Professor Liu Hong from the Affiliated Hospital of Dermatology, Shandong First Medical University combined clinical and etiology to study pustular psoriasis, comprehensively explaining the etiology and pathogenesis of generalized pustular psoriasis.

From the perspective of the treatment of psoriasis and its comorbiditis, Professor Xia Jianxin from the Second Hospital of Jilin University brought us the recommended diagnosis and treatment plan for psoriasis complicated with inflammatory bowel disease, diabetes, heart disease and malignant tumor, emphasizing the important role of biological agents in the treatment of psoriasis comorbiditis.

The Academic Satellite Association was co-chaired by Professor Zhang Furen, President of the Affiliated Hospital of Dermatology, Shandong First Medical University, and Professor Li Yuzhen, Professor of the Second Affiliated Hospital of Harbin Medical University.

First affiliated hospital of anhui medical university professor zhang rob is introduced for us, especially the mechanism of action of single resistance and clinical research, professor zhang pointed out that rob, especially sheet resistance in targets for treatment of patients with psoriasis "spear" and "shield" relations ACTS as a "shield" role, can be more comprehensive inhibition of IL - 17 a family, at the same time can be more safe and fast work, clear skin ability is more outstanding.

Zhang Xibao, a professor from Guangzhou Institute of Dermatology, introduced the routine external medication for psoriasis, and compared the advantages of emboke, a new biological agent for external use, pointing out that it is more economical and safe, and can avoid damaging the skin barrier function.

Professor Zhang Chunlei from The Third Hospital of Peking University introduced the cost-effective long-term treatment of the majority of patients with psoriasis, and introduced the necessity of standardized long-term use of biological agents to reduce the probability of recurrence of psoriasis from the level of molecular data.

Due to disease, skin disease hospital in dalian Lv Chengzhi professor online as we introduced the standardization treatment psoriasis topical drugs, stressed in the clinical should avoid the use of non-standard hormone of HPA axis suppression, against psoriasis topical medications should be adhering to the sequential, joint, law, the principle of all the way, at the same time introduces the soft hormone for domestic economic universality of patients.

Professor Sun Liangdan from the First Affiliated Hospital of Anhui Medical University introduced benweimud (Xinbike) as a new choice for the treatment of psoriasis, and pointed out that benweimud (Xinbike) can specifically bind TO AhR, thus regulating the inflammatory response mediated by AhR pathway, which is a safe and effective new drug independently developed in China.

Professor Zhang Xuejun from the First Affiliated Hospital of Anhui Medical University introduced the clinical data interpretation of Tilapizumab in moderate and severe psoriasis. Zhang pointed out that the drug has a higher safety in patients with moderate to severe plaque psoriasis, and the effect of this new class of drugs targeting IL-23 is comparable to that of targeted biological agents targeting the IL-17 pathway.

Professor Yu Chen from the First Affiliated Hospital of the Fourth Military Medical University introduced the clinical research of supramolecular active zinc in the treatment of scalp psoriasis, and introduced the safety and tolerability of supramolecular salicylic acid system in the treatment of psoriasis. Its efficacy is comparable to that of standard treatment drugs, with good safety and convenience.

The first affiliated hospital of anhui medical university professor yeung sum introduces the applications of silver in dermatology, le silver has to go to the filings, moisturizing skin care effect, have anti-inflammatory effects at the same time to repair the skin barrier, at the same time, combined with clinical data interpretation of the music silver dressings in the treatment of seborrheic dermatitis to improve the effectiveness of desquamation and lesion area.

Professor Shi Yuling from Shanghai Dermatology Hospital brought us the topic of "Discussion on solutions for disobedience in patients with psoriasis". Professor Shi Shared effective solutions for poor clinical efficacy caused by poor compliance of patients.

From the pathogenic basis of psoriasis to the clinical diagnosis and treatment, the experts Shared the latest clinical observation progress of biological agents and other drugs in a simple and profound way, which provided valuable information for us to follow up the latest trends of psoriasis medication and grasp the latest specifications of medication!

On the afternoon of 24th, the "Special session on Basic Research and Clinical Diagnosis and Treatment of Psoriasis" of the 4th China Psoriasis Congress continued. Report content involves skin micro ecological anomalies and the role of skin barrier damage in patients with psoriasis, infection the diagnosis and treatment of psoriasis attachment points, psoriasis and preliminary exploration of cognitive impairment, and recent advances in the treatment of children pustular psoriasis and psoriasis system, biological preparation time psoriasis keep with break, biological agents for the treatment of a dermatologist in psoriasis, the application of the special groups, FOXE1 and its mechanism of action of inhibitors in patients with psoriasis, new progress of mesenchymal stem cells to treat psoriasis and psoriasis treatment target new mirna - 210, etc.

In the afternoon, the first-half conference report was co-chaired by Professor Xiao Fengli from the first Affiliated Hospital of Anhui Medical University and Professor Liu Taofeng from the first Affiliated Hospital of Anhui University of Chinese Medicine.

Psoriasis is a chronic refractory hereditary skin disease that is easy to relapse. The basic research on psoriasis is gradually deepened, and the therapeutic drugs and methods are constantly updated and improved. Quan Sheng, a professor from Wuxi Second People's Hospital affiliated to Nanjing Medical University, explored the influence of microbial interaction on epidermal microecology from three aspects: sebaceous gland function and local PH level, competition inhibition between microorganisms and skin barrier condition, and described the latest research progress in this field.

Second people's hospital of chengdu yong-hong lu professor points out that the attachment point inflammation is one of the earliest symptoms in patients with psoriatic arthritis, high incidence but diagnostic rate is low, mechanical stress for the key triggers, IL - 17 a is involved in inflammation of the skin lesion, attachment points and the core of the subsequent structural failure cytokines, leads to a lower quality of life and irreversible bone injury.

Qiao Jianjun, a professor from the First Affiliated Hospital of Zhejiang University School of Medicine, showed and explained different types of pustular psoriasis, and expounded the traditional treatment, external and local treatment and biologic treatment of pustular psoriasis, so as to provide guidance for clinical medication.

Professor Zhu Wu from Xiangya Hospital of Central South University preliminarily explored and analyzed the relationship between psoriasis and neurological diseases and mental diseases from the aspects of genetic factors, psoriasis comorbid diseases, inflammatory mediators and brain-skin axis, and concluded that the risk of cognitive dysfunction in patients with psoriasis increased.

Affiliated to the capital university of medical sciences, Beijing children's hospital professor zi-gang xu from children's perspective of the treatment of psoriasis, psoriasis drug in the treatment of challenges and difficulties, face the children Shared the antibiotics, vitamin A acid, methotrexate, ring spore type and biological agents in children moderately severe plaque psoriasis cases of curative effect and adverse reaction, the psoriasis treatment to children have higher clinical guiding significance.

The second half meeting in the afternoon was co-chaired by Professor Lu Yan from Jiangsu Provincial People's Hospital and Professor Liu Shengxiu from the First Affiliated Hospital of Anhui Medical University.

Microrna-210, a new target for the treatment of psoriasis, was proposed by Professor Zhao Ming from the second Hospital of Xiangia, Central South University from the perspective of epigenetics. This molecule is overexpressed in patients with psoriasis vulgare and psoria-like mouse models. Microrna-210 overexpression induces Th17 and Th1 cell differentiation, promotes the expression of inflammatory factors IL-17 and IFN-, and induces skin inflammation.

In the treatment of psoriasis, the emergence of biological agents has played a "milestone" role, the application is increasingly extensive. Professor Liu Guoyan from The Affiliated Hospital of Weifang Medical College gave a talk on the application of biological agents in the special population of psoriasis (including the elderly, pregnant women, comorbid diseases, infections and vaccines, etc.). More and more attention has been paid to the safety of biological agents, which has enriched the clinical practice of the treatment of special population of psoriasis.

Dr. Liu Meng, a team of Professor Zheng Yan from the Second Affiliated Hospital of Xi 'an Jiaotong University, explained the mechanism of FOXE1 and its inhibitors in psoriasis, suggesting that FOXE1 is closely related to skin tumors and psoriasis. Bioinformatics analysis showed that FOXE1 expression was significantly increased in psoriasis skin lesions and psoriatic cell models, and the molecule was involved in the pathogenesis of psoriasis by promoting cell proliferation, cycle and inflammatory factor expression.

Professor Zhang Zhenghua from Huashan Hospital of Fudan University gave a lecture on the origin and development of mesenchymal stem cells and their status and progress in the treatment of psoriasis, and pointed out that mesenchymal stem cells have a broad application prospect in the treatment of psoriasis.

Professor Lu Yan from Jiangsu Provincial People's Hospital talked about the defense and attack of dermatologists in the treatment of psoriasis in the era of biological agents, put forward the careful selection of traditional treatment and the combination of traditional classical treatment, and paid attention to the quality of life of patients with psoriasis and the progress of biological agents, and emphasized the concept of putting people first and combining attack and defense.

Dr. Liu Xinxin, a team of Professor Hongxiang Chen from The Union Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology, gave a lecture on the preliminary exploration of pro-inflammatory regression strategies in inflammation control of psoriasis, and proposed a new direction for basic research on psoriasis.

In the academic report exchange meeting in the afternoon, all the experts presented us with a wonderful academic feast. Each speaker analyzed the status quo of basic research and treatment of psoriasis from different perspectives, and comprehensively interpreted the latest research progress of psoriasis. It is believed that this academic conference will play a positive role in promoting the diagnosis and treatment of dermatologists and the prevention, diagnosis and treatment of psoriasis in China.

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