Psoriasis has a certain genetic probability. It is now believed that psoriasis is one of the typical complex diseases and a polygenic hereditary disease. In other words, on the basis of heredity, psoriasis may also be affected by a variety of factors such as mental factors, skin trauma, and in vivo and in vitro environmental factors. Specific to the psoriasis patients, the causes of the disease are different, and even in the same psoriasis patients there are multiple predisposing factors.

        The presence of genetic factors in psoriasis is now well recognized, as evidenced by three aspects of research.

        First, a considerable number of patients were clinically found to have psoriasis in their family members, i.e., genetic genealogy investigation. In the investigation report of home and abroad, the patient that has family venereal history is in about 10% ~ 30%. In our long-term follow-up study, 279 of 943 patients had a history of family history. Accounted for 29.5%. Thirty-two people had the disease in three successive generations, and eight in 25 in a family of three generations were related, but this was rare.

        Secondly, the incidence of psoriasis in twins was investigated.

        Thirdly, studies on leukocyte blood groups have also proved that psoriasis has genetic factors.

        Because the study of double cell pair and the study of leukocyte blood group involves more profound professional theoretical knowledge, here is not introduced. The results also support the existence of familial genetic predisposition in psoriasis.

        The genetic factors of psoriasis have been determined, but many problems, such as how psoriasis is inherited, whether its genetic material (gene) is single or multiple, where the gene is located and its composition, have not been thoroughly studied. These problems are the hot spots of modern scientists' research. People expect to solve the problem of prevention and treatment of this disease thoroughly through such research, but it is very difficult.

        For patients and their families, the main concern is whether the disease will continue to be passed on to the next generation. We said that the presence of genetic factors does not mean that the offspring must have psoriasis, as mentioned above, there is no psoriasis in the family or the vast majority of patients. There are two problems to be explained here. First, if you already have psoriasis and there is no psoriasis patient in your family, you should not pay too much attention to the existence of genetic factors, because how genetic factors work is an extremely complex problem and it is difficult to understand without some professional knowledge. Secondly, if you have psoriasis there is no need to worry too much about the hereditary disease, because successive generations of psoriasis appear in the family is after all a minority. Even if the offspring have a patient, not every member of the disease, after all, the members of the disease is a minority. Moreover, it is an objective existence, and fear does not solve the problem, because there is no way to predict the extent of the current science. Furthermore, the fact that many psoriasis patients have never been found in their grandparents shows that healthy people do not necessarily have no genetic factors for the disease, nor can they guarantee that their offspring will not have psoriasis patients, of course, the chance of appearance is less after all.

        There is another point to explain, some people believe that the psoriasis patients during the period of the disease will be passed on to the offspring, after the cure of fertility will not be inherited, this is a misunderstanding. The genetic factors carried by patients will not change because of whether the disease is cured or not, on the contrary, many drugs for the treatment of psoriasis have teratogenic effect, if the use of such drugs to make the lesion subside immediately after pregnancy, there is a risk of teratogenesis, which is not advisable.